To use these compression cubes, simply put your clothes or other items inside. Roll them up to save more space and then zip them up. For better organization, you can use different cubes for different types of things, like one for shirts and another for pants. When packing, place the cubes neatly in your suitcase or backpack. As for maintenance, you can wash them by hand or in a gentle cycle in the washing machine. Avoid using harsh chemicals. Also, don't overstuff the cubes as it might damage the zippers or reduce their compression ability.